Publications Sorted

Publications Sorted2024-07-01T23:53:45+00:00
83. Contrasteric glycosylations of cotylenol and 1,2-diols by virtual linker selection2024-09-12T20:25:18+00:00

83. Snelson, D.;† Ting, S.;† Shenvi, R. A. “Contrasteric glycosylations of cotylenol and 1,2-diols by virtual linker selectionChemRxiv DOI: 10.26434/chemrxiv-2024-j7c15

82. On the role of thermally activated EDA complexes in decarboxylative cross-coupling2024-09-12T20:22:14+00:00

82. Dao, N.; Shenvi, R. A. On the role of thermally activated EDA complexes in decarboxylative cross-coupling Tetrahedron 2024 [invited, T. Maimone award issue], accepted.

81. Total synthesis of twenty-five picrotoxanes by virtual library selection2024-08-03T17:14:09+00:00

81. Li, C.; Shenvi, R. A. Total synthesis of twenty-five picrotoxanes by virtual library selection ChemRxiv DOI: 10.26434/chemrxiv-2024-g8j1r.

80. Metal-Hydride C–C Cross-Coupling of Alkenes Through a Double Outer-Sphere Mechanism2024-07-01T23:47:34+00:00

80. Dao, N.; Gan, X.-c.; Shenvi, R. A. Metal-Hydride C–C Cross-Coupling of Alkenes Through a Double Outer-Sphere Mechanism J. Org. Chem. accepted.

79. Natural product synthesis in the 21st century: beyond the mountain top2024-06-28T05:57:47+00:00

79. Shenvi, R. A. Natural product synthesis in the 21st century: beyond the mountain top ACS Cent. Sci. 2024, online.

78. Methylation Confers Accessibility, Stability and Selectivity to Picrotoxinin2024-06-28T05:57:27+00:00

78. Tong, G.; Griffin, S.; Sader, A.; Crowell, A. B.; Beavers, K.; Watson, J.; Buchan, Z.; Chen, S.; Shenvi, R. A. C5 Methylation Confers Accessibility, Stability and Selectivity to Picrotoxinin Nature Commun. 2023, 14, 8308.
ChemRxiv DOI: 10.26434/chemrxiv-2022-0l4nt

77.  Carbon Quaternization of Redox Active Esters and Olefins via Decarboxylative Coupling2024-06-28T05:59:33+00:00

77. Gan, X.-c.;† Zhang, B.;† Dao, N.;† Bi, C.; Pokle, M.; Kan, L.; Collins, M. R.; Tyrol, C. C.; Bolduc, P. N.; Nicastri, M.; Kawamata, Y.; Baran, P. S.; Shenvi, R. A. Carbon Quaternization of Redox Active Esters and Olefins via Decarboxylative CouplingScience 2024, 384, 113. †co-first authors

76. Alkene hydrobenzylation by a single catalyst that mediates iterative outer-sphere steps2024-06-28T06:00:41+00:00

76. Kong, L.;† Gan, X.-c.;† van der Puyl-Lovett, V. A.;† Shenvi, R. A. Alkene hydrobenzylation by a single catalyst that mediates iterative outer-sphere stepsJ. Am. Chem. Soc2024, 146, 2351.
ChemRxiv 10.26434/chemrxiv-2023-zw9c2 2023, †co-first authors.

75. Inner- and outer-sphere cross-couplings for high Fsp3 fragments in natural product space2024-06-28T06:02:10+00:00

75. Kotesova, S.; Shenvi, R. A. Inner- and outer-sphere cross-couplings for high Fsp3 fragments in natural product spaceAcc. Chem. Res. 2023, 56, 3089.

74. Synthesis of (–)-cotylenol, a 14-3-3 molecular glue component2024-06-28T06:03:08+00:00

74. Ting, S.;† Snelson, D.;† Huffman, T. R.; Kuroo, A.; Sato, R.; Shenvi, R. A. Synthesis of (–)-cotylenol, a 14-3-3 molecular glue componentJ. Am. Chem. Soc. 2023, 145, 20634. †co-first authors

73. Iron-catalyzed hydrobenzylation: stereoselective synthesis of (–)-eugenial C2024-06-28T06:04:59+00:00

73. Gan, X.-c.;§ Kotesova, S.;§ Castanedo, A.; Green, S. A.; Møller, S. L. B.; Shenvi, R. A. Iron-catalyzed hydrobenzylation: stereoselective synthesis of (–)-eugenial C. J. Am. Chem. Soc. 2023, 145, 15714. §co-first authors

72. A route to potent, selective and biased salvinorin chemical space2024-06-28T06:08:09+00:00

72. Hill, S. J.§; Dao, N.§; Dang, V.; Stahl, E.; Bohn, L. Shenvi, R. A. A route to potent, selective and biased salvinorin chemical spaceACS Cent. Sci.2023, online. §co-first authors

71. Early Childhood Care as an Academic: The Slow Burn2024-06-28T06:07:03+00:00

71. Shenvi, R. A. Early Childhood Care as an Academic: The Slow BurnAngew. Chem. Int. Ed.2023, in press [Ihr verborgenes Leben (Their Hidden Lives) Essay Series].

70. Manganese, iron and cobalt-catalyzed radical olefin hydrofunctionalization2024-06-28T06:09:18+00:00

70. van der Puyl, V. A.; Shenvi, R. A. Manganese, iron and cobalt-catalyzed radical olefin hydrofunctionalization Science of Synthesis, 2.14: Base Metal Catalysis, 2023, Ed. N. Yoshikai.

69. Synthesis of psychotropic alkaloids from Galbulimima2024-06-28T06:16:15+00:00

69. Woo, S.; Landwehr, E.; Shenvi, R. A. Synthesis of psychotropic alkaloids from Galbulimima Tetrahedron 2022, 126, 133064. [In celebration of the 65th anniversary of Tetrahedron Publications]

68. Asymmetric syntheses of (+)- and (–)-collybolide enable re-evaluation of kappa-opioid receptor agonism2024-06-28T06:17:15+00:00

68. Shevick, S. L.; Freeman, S.; Tong, G.; Russo, R. J.; Bohn, L. M.; Shenvi, R. A. Asymmetric syntheses of (+)- and (–)-collybolide enable re-evaluation of kappa-opioid receptor agonism ACS Cent. Sci., 2022, 8, 948–954. DOI: https://doi.org/10.1021/acscentsci.2c00442.
ChemRxiv DOI: 10.26434/chemrxiv-2021-rtxqf

67. Synthesis and target annotation of GB182024-06-28T06:17:58+00:00

67. Woo, S.; Shenvi, R. A. Synthesis and target annotation of GB18Nature2022, DOI: 10.1038/s41586-022-04840-9.
ChemRxiv DOI: 10.26434/chemrxiv-2022-cs8v5

66. Concise syntheses of GB22, GB13 and himgaline by cross-coupling and complete reduction2024-06-28T06:19:13+00:00

66. Landwehr, E. M.; Baker, M. A.; Oguma, T.; Burdge, H. E.; Kawajiri, T.; Shenvi, R. A. Concise syntheses of GB22, GB13 and himgaline by cross-coupling and complete reduction. Science, 2022, 375, 1270–1274.
ChemRxiv DOI: 10.26434/chemrxiv.8263415.v1

65.  Stereodivergent attached ring synthesis via non-covalent interactions: a short formal synthesis of merrilactone2024-07-01T23:48:24+00:00

65. Huffman, B. J.; Chu, T.; Hanaki, Y.; Wong, J. J.; Chen, S.; Houk, K. N.; Shenvi, R. A. Stereodivergent attached ring synthesis via non-covalent interactions: a short formal synthesis of merrilactone A Angew. Chem. Int. Ed. 2022, 61, e202114514.

64. Revision of the unstable picrotoxinin hydrolysis product2024-06-28T06:20:51+00:00

64. Tong, G.; Shenvi, R. A. Revision of the unstable picrotoxinin hydrolysis product Angew. Chem. Int. Ed. 2021, 60, 19113.

63. Cobalt-catalyzed alkene hydrogenation by reductive turnover2024-06-28T06:22:16+00:00

63. van der Puyl, V.; McCourt, R. O.; Shenvi, R. A. Cobalt-catalyzed alkene hydrogenation by reductive turnover Tetrahedron Lett. 2021, 72, 153047. On the occasion of the 2020 Tetrahedron Prize to Dale Boger.

62. Natural Product Synthesis through the Lens of Informatics2024-06-28T06:22:54+00:00

62. Woo, S.; Shenvi, R. A. Natural Product Synthesis through the Lens of Informatics Acc. Chem. Res. 2021, 54, 1157–1167.

61. Change the channel: CysLoop receptor antagonists from Nature2024-06-28T06:23:41+00:00

61. Tong, G.; Baker, M. A.; Shenvi, R. A. Change the channel: CysLoop receptor antagonists from Nature. Pest Manag. Sci. 2020, 77, 3650–3662. [Special Issue honoring Tom Sparks for the Kenneth Spencer Award]

60. Catalytic hydrogen atom transfer to alkenes: a roadmap for metal hydrides and radicals2024-06-28T06:24:36+00:00

60. Shevick, S. L.; Wilson, C. V.; Kotesova, S.; Kim, D.; Holland, P. L.; Shenvi, R. A. Catalytic hydrogen atom transfer to alkenes: a roadmap for metal hydrides and radicals. Chem. Sci. 2020, 12401–12422.

59. Synthetic, Mechanistic and Biological Interrogation of Ginkgo biloba Chemical Space en route to (–)-Bilobalide2024-06-28T06:25:20+00:00

59. Demoret, R. M.; Baker, M. A.; Ohtawa, M.; Chen, S.; Lam, C.-C.; Khom, S.; Roberto, M.; Forli, S.; Houk, K.; Shenvi, R. A. Synthetic, Mechanistic and Biological Interrogation of Ginkgo biloba Chemical Space en route to (–)-BilobalideJ. Am. Chem. Soc. 2020, 142, 18599–18618.ChemRxiv DOI: 10.26434/ chemrxiv.12132939.v2

58. Chemical Syntheses of the salvinorin chemotype of KOR agonist2024-06-28T06:26:17+00:00

58. Hill, S. J.; Brion, A. U. C. M.; Shenvi, R. A. Chemical Syntheses of the salvinorin chemotype of KOR agonistNat. Prod. Rep. 2020, 37, 1478–1496.

57. Total Synthesis of (–)-Picrotoxinin2024-06-28T06:27:02+00:00

57. Crossley, S. W. M.; Tong, G.; Lambrecht, M. J.; Burdge, H. E.; Shenvi, R. A. Total Synthesis of (–)-Picrotoxinin J. Am. Chem. Soc. 2020, 142, 11376–11381.
ChemRxiv DOI: 10.26434/chemrxiv.8263415.v1

56. Cycloisomerization of olefins in water2024-06-28T06:27:52+00:00

56. Matos, J. L. M.; Green, S. A.; Chun, Y; Dang, V. Q.; Dushin, R. G.; Richardson, P.; Chen, J. S.; Piotrowski, D. W.; Paegel, B. M.; Shenvi, R. A. Cycloisomerization of olefins in waterAngew. Chem. Int. Ed. 2020, 59, 12998–13003.
ChemRxiv: 10.26434/chemrxiv.11977917.v1

55. Concise Synthesis of GB22 by Endo-Selective Siloxycyclopropane Arylation2024-06-28T06:28:30+00:00

55. Burdge, H. E.; Oguma, T.; Kawajiri, T.; Shenvi, R. A. Concise Synthesis of GB22 by Endo-Selective Siloxycyclopropane Arylation ChemRxiv DOI: 10.26434/chemrxiv.8263415.v1 .

54. Electronic Complementarity Permits Hindered Butenolide Heterodimerization and Discovery of Novel cGAS/STING Pathway Antagonists2024-06-28T06:30:25+00:00

54. Huffman, B. J.; Chen, S.; Schwarz, J. L; Plata, R. E.; Chin, E.; Houk, K. N.; Lairson, L. L.; Shenvi, R. A. Electronic Complementarity Permits Hindered Butenolide Heterodimerization and Discovery of Novel cGAS/STING Pathway AntagonistsNature Chem. 2020, 12, 310–317.

53. Alkene Hydroarylation by Co/Ni Dual Catalysis2024-06-28T06:30:06+00:00

53. Shevick, S. L.; Baker, M. A.; Shenvi, R. A. Alkene Hydroarylation by Co/Ni Dual Catalysis, Cell: Trends in Chemistry2019, 1, 540–541.

52. Chapter 7. Markovnikov Functionalization by Hydrogen Atom Transfer2024-06-28T06:31:34+00:00

52. Matos, J. L. M.; Green, S. A.; Shenvi, R. A. Chapter 7. Markovnikov Functionalization by Hydrogen Atom TransferOrganic Reactions2019, 100, 383–470.

51. Concise Asymmetric Synthesis of (–)-Bilobalide2024-06-28T06:32:34+00:00

51. Baker, M.; Demoret, R.; Ohtawa, M.; Shenvi, R. A. Concise Asymmetric Synthesis of (–)-Bilobalide Nature 2019, 575, 643–646. DOI: 10.1038/s41586-019-1690-5. ChemRxiv DOI: 10.26434/chemrxiv.8202053.v1 Featured in Org. Chem. Highlights

50. Hydroalkylation of Olefins to form Quaternary Carbons2024-06-28T06:33:15+00:00

50. Green, S. A.; Huffman, T. R.; McCourt, R. O.; van der Puyl, V.; Shenvi, R. A. Hydroalkylation of Olefins to form Quaternary Carbons J. Am. Chem. Soc. 2019, 141, 7709-7714.

49. Reanalysis of Lindenatriene, a Building Block for the Synthesis of Lindenane Oligomers2024-06-28T06:33:53+00:00

49. Martinez, R.; Burdge, H.; Shenvi, R. A. Reanalysis of Lindenatriene, a Building Block for the Synthesis of Lindenane Oligomers Tetrahedron 2019, 75, 3140-3144. [invited manuscript for Ryan’s Tetrahedron Young Investigator Award 2019]

48. Natural Products in the ‘Marketplace’: Interfacing Synthesis and Biology2024-06-28T06:34:28+00:00

48. Huffman, B.; Shenvi, R.A. Natural Products in the ‘Marketplace’: Interfacing Synthesis and Biology J. Am. Chem. Soc. 2019, 141, 3332-3346.

47. Intermolecular Heck Coupling with Hindered Alkenes Directed by Potassium Carboxylates2024-06-28T06:35:04+00:00

47. Huffman, T.; Wu, Y.; Emmerich, A.; Shenvi, R.A. Intermolecular Heck Coupling with Hindered Alkenes Directed by Potassium Carboxylates Angew. Chem. Int. Ed. 2019, 58, 2371-2376.

46. Branch-Selective Addition of Unactivated Olefins into Imines and Aldehydes2024-06-28T06:35:42+00:00

46. Matos, J.L.M.; Vásquez-Céspedes, S.; Gu, J.; Oguma, T.; Shenvi, R.A. Branch-Selective Addition of Unactivated Olefins into Imines and Aldehydes J. Am. Chem. Soc. 2018, 140, 16976–16981.

45. The High Chemofidelity of Metal-Catalyzed Hydrogen Atom Transfer 2024-06-28T06:36:36+00:00

45. Green, S.A.; Crossley, S.W.M.; Matos, J.L.M.; Vásquez-Céspedes, S.; Shevick, S. L.; Shenvi, R. A. The High Chemofidelity of Metal-Catalyzed Hydrogen Atom Transfer Acc. Chem. Res., 2018, 51, 2628–2640.

44. Mechanistic Interrogation of Co/Ni-Dual Catalyzed Hydroarylation2024-06-28T06:37:09+00:00

44. Shevick, S. L.; Obradors, C.; Shenvi, R. A. Mechanistic Interrogation of Co/Ni-Dual Catalyzed Hydroarylation J. Am. Chem. Soc. 2018,140, 12056–12068.

43. Iron-Nickel Dual-Catalysis: A New Engine for Olefin Functionalization2024-06-28T06:37:49+00:00

43. Green, S. A.; Vásquez-Céspedes, S.; Shenvi, R. A. Iron-Nickel Dual-Catalysis: A New Engine for Olefin Functionalization. J. Am. Chem. Soc. 2018, 140, 11317–11324

42. Pharmacological characterization of the neurotrophic sesquiterpene jiadifenolide reveals a non-convulsant signature and potential for progression in neurodegenerative disease studies2024-06-28T06:38:26+00:00

42. Jeffrey M. Witkin, Ryan A. Shenvi, Xia Li, Scott D. Gleason, Julie Weiss, Denise Morrow, John T. Catow, Mark Wakulchik, Masaki Ohtawa, Hai-Hua Lu, Michael D. Martinez, Jeffrey M. Schkeryantz, Timothy S. Carpenter, Felice C. Lightstone, Rok Cerne Pharmacological characterization of the neurotrophic sesquiterpene jiadifenolide reveals a non-convulsant signature and potential for progression in neurodegenerative disease studiesBiochem. Pharm. 2018, 155, 61–70.
DOI: 10.1016/j.bcp.2018.06.022

41. Mechanism of Action of the Cytotoxic Asmarine Alkaloids2024-06-28T06:39:12+00:00

41. Lambrecht, M.; Kelly, J. W.; Shenvi, R. A. Mechanism of Action of the Cytotoxic Asmarine AlkaloidsACS Chem. Bio. 2018, 13, 1299–1306. DOI: 10.1021/acschembio.8b00096

40. A Review of Salvinorin Analogs and their Kappa-Opioid Receptor Activity2024-06-28T06:39:45+00:00

40. Roach, J. J.; Shenvi, R. A. A Review of Salvinorin Analogs and their Kappa-Opioid Receptor Activity. Bioorg. Med. Chem. Lett. 2018, 28, 1436–1445. DOI: 10.1016/j.bmcl.2018.03.029

39. O6C-20-nor-SalA is a stable and potent KOR agonist2024-06-28T06:40:16+00:00

39. Hirasawa, S.; Cho, M.; Brust, T. F.; Roach, J. J.; Bohn, L. M.; Shenvi, R. A. O6C-20-nor-SalA is a stable and potent KOR agonistBioorg. Med. Chem. Lett. 2018, 28, 2770–2722. Special Issue dedicated to Dale Boger.

38. Dynamic Strategic Bond Analysis Yields a 10-step Synthesis of 20-nor-SalA, a Potent Κ-OR Agonist2024-06-28T06:41:04+00:00

38. Roach, J. J.; Sasano, Y.; Schmid, C. L.; Zaidi, S.; Katrich, V.; Stevens, R. C.; Bohn, L. M.; Shenvi, R. A. Dynamic Strategic Bond Analysis Yields a 10-step Synthesis of 20-nor-SalA, a Potent Κ-OR Agonist. A(CS)2 2017, 3, 1329–1336.
ChemRxiv DOI: 10.26434/chemrxiv.5318188

  • #1 Most Viewed Article on ChemRxiv, Aug-Dec 2017.
  • Highlighted by Tien Ngyuen in C&EN, Sept. 1 2017.
  • See article on SlashGear by Brittany Rosen, Sept. 11, 2017
  • See article on Gizmodo by Ryan Mandalbaum, Sept. 12, 2017
  • See article on Geek by Daniel Starkey, Sept. 12, 2017
  • See article on Wired by Matthew Simon, Jan. 8, 2018
37. Synthesis of (–)-11-O-Debenzoyltashironin: Neurotrophic Sesquiterpenes Cause Hyperexcitation2024-06-28T06:41:41+00:00

37. Ohtawa, M.; Krambis, M. J.; Cerne, R.; Schkeryantz, J.; Witkin, J. M.; Shenvi, R. A. Synthesis of (–)-11-O-Debenzoyltashironin: Neurotrophic Sesquiterpenes Cause Hyperexcitation. J. Am. Chem. Soc. 2017, 139, 9637-9644.
Featured in Org. Chem. Highlights

36. Stereocontrolled Synthesis of Kalihinol C2024-06-28T06:42:20+00:00

36. Reiher, C. A.; Shenvi, R. A. Stereocontrolled Synthesis of Kalihinol CJ. Am. Chem. Soc. 2017, 139, 3647-3650.

35. Branch-Selective Hydroarylation: Iodoarene-Olefin Cross Coupling2024-06-28T06:42:52+00:00

35. Green, S. A.; Matos, J. L. M.; Yagi, A.; Shenvi, R. A. Branch-Selective Hydroarylation: Iodoarene-Olefin Cross Coupling. J. Am. Chem. Soc. 2016, 138, 12779-12782.

34. And You, of Tender Years2024-06-28T06:43:33+00:00

34. Shenvi, R. A. And You, of Tender Years. Chem. 2016, 1, 331.

33. Mn, Fe, and Co-Catalyzed Radical Hydrofunctionalizations of Olefins2024-06-28T06:44:12+00:00

33. Crossley, S. W. M.; Martinez, R. M.; Obradors, C.; Shenvi, R. A. Mn, Fe, and Co-Catalyzed Radical Hydrofunctionalizations of OlefinsChem. Rev. 2016, 116, 8912-9000.

32. Synthesis and Sulfur Electrophilicity of the Nuphar Thiaspirane Pharmacophore2024-06-28T06:44:52+00:00

32. Tada, N.; Jansen, D. J.; Mower, M. P.; Blewett, M. M.; Umotoy, J. C.; Cravatt, B. F.; Wolan, D. W.; Shenvi, R. A. Synthesis and Sulfur Electrophilicity of the Nuphar Thiaspirane PharmacophoreACS Cent. Sci. 2016, 2, 401-408.

31. Diisocyanoadociane and Liver-Stage Antiplasmodial Activity of the Isocyanoterpene Class2024-06-28T06:45:33+00:00

31. Lu, H.-H.; Pronin, S. V.; Antonova-Koch, Y.; Meister, S.; Winzeler, E. A.; Shenvi, R. A. Synthesis of (+)-7,20-Diisocyanoadociane and Liver-Stage Antiplasmodial Activity of the Isocyanoterpene ClassJ. Am. Chem. Soc. 2016, 138, 7268-7271.

30. Synthesis of the Privileged 8-Arylmenthol Class by Radical Arylation of Isopulegol2024-06-28T06:46:18+00:00

30. Crossley, S. W. M.; Martinez, R. M.; Zuluaga, S. G.; Shenvi R. A. Synthesis of the Privileged 8-Arylmenthol Class by Radical Arylation of IsopulegolOrg. Lett. 2016, 18, 2620-2623.

29. An Exceptional Reductant for Metal-Catalyzed Hydrogen Atom Transfers2024-06-28T06:46:50+00:00

29. Obradors, C. L.; Martinez, R.; Shenvi, R. A. Ph(i-PrO)SiH2: An Exceptional Reductant for Metal-Catalyzed Hydrogen Atom TransfersJ. Am. Chem. Soc. 2016, 138, 4962-4971.

28. Neurite Outgrowth Enhancement by Jiadifenolide: Possible Targets2024-06-28T06:47:33+00:00

28. Shenvi, R. A. Neurite Outgrowth Enhancement by Jiadifenolide: Possible Targets. Nat. Prod. Rep. 2016, 33, 535-539.

27. Reinventing Radical Reactions2024-06-28T06:48:04+00:00

27. Shenvi, R. A. Reinventing Radical Reactions. SynLett Cluster (Ed. T. Rovis and R. A. Shenvi). 2016, 27, 678-679.

26. Conjuring a Supernatural Product – Delmarine2024-06-28T06:48:36+00:00

26. Wan, K. K.; Shenvi, R. A. Conjuring a Supernatural Product – DelmarineSynLett (invited Accounts). 2016, 27, 1145-1164.

25. Synthesis of Lepadiformine Using a Hydroamination Transform2024-06-28T06:49:15+00:00

25. Tabor, M. G.; Shenvi, R. A. Synthesis of Lepadiformine Using a Hydroamination Transform. Org. Lett. 2015, 17, 5776.

24. Eight-Step, Gram-Scale Synthesis of (–)-Jiadifenolide2024-06-28T06:49:49+00:00

24. Lu, H.-H.; Martinez, M. D.; Shenvi, R. A. Eight-Step, Gram-Scale Synthesis of (–)-Jiadifenolide. Nature Chem. 2015, 7, 604-607.

23. A Longitudinal Study of Alkaloid Synthesis Reveals Functional Group Interconversions (FGIs) as Bad Actors2024-06-28T06:50:18+00:00

23. Crossley, S. W. M.; Shenvi, R. A. A Longitudinal Study of Alkaloid Synthesis Reveals Functional Group Interconversions (FGIs) as Bad Actors. Chem. Rev. 2015, 115, 9465-9531.

22. Nitrosopurines en route to Potent Asmarine Cytotoxins.2024-07-01T23:50:59+00:00

22. Wan, K. K.; Iwasaki, K.; Umotoy, J. C.; Wolan, D.; Shenvi, R. A. Nitrosopurines en route to Potent Asmarine Cytotoxins. Angew.Chem. Int. Ed. 2015, 127, 2440-2445.

21. Syntheses and Biological Studies of Marine Terpenoids Derived from Inorganic Cyanide2024-06-28T06:51:26+00:00

21. Shenvi, R. A.; Schnermann, M. J. Syntheses and Biological Studies of Marine Terpenoids Derived from Inorganic Cyanide. Nat. Prod. Rep. 2015, 32, 543-577.

20. Simple, Chemoselective, Catalytic Olefin Isomerization2024-06-28T06:52:28+00:00

20. Crossley, S. W. M.; Barabé, F.; Shenvi, R. A. Simple, Chemoselective, Catalytic Olefin Isomerization. J. Am. Chem. Soc2014, 136, 16788.​

Isomerization pre-catalyst now available from Sigma-Aldrich

19. Synthesis of medicinally relevant terpenes: reducing the cost and time of drug discovery2024-06-28T06:53:03+00:00

19. Jansen, D. J.; Shenvi, R. A. Synthesis of medicinally relevant terpenes: reducing the cost and time of drug discovery. Future Med. Chem.2014, 6, 1127.

18. Simple, Chemoselective Hydrogenation with Thermodynamic Stereocontrol2024-06-28T06:53:50+00:00

18. Iwasaki, K.; Wan, K. K.; Oppedisano, A.; Crossley, S. W. M.; Shenvi R. A. Simple, Chemoselective Hydrogenation with Thermodynamic Stereocontrol. J. Am. Chem. Soc. 2014, 136, 1300-1303.

17. Stereoinversion of tertiary alcohols to tertiary alkyl isonitriles and amines2024-06-28T06:54:48+00:00

17. Pronin, S. V.; Reiher, C. A.; Shenvi, R. A. Stereoinversion of tertiary alcohols to tertiary alkyl isonitriles and amines. Nature. 2013, 501, 195-199.

  • Featured by TCI Chemicals
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  • Selected for highlight in C&EN: “2013’s Notable Advances” 2013, 91, 15.
16.  Synthesis of (–)-Neothiobinupharidine2024-06-28T06:55:19+00:00

16. Jansen, D. J.; Shenvi, R. A. Synthesis of (–)-Neothiobinupharidine. J. Am. Chem. Soc. 2013, 135, 1209-1212.

15. Synthesis of a Potent Antimalarial Amphilectene2024-06-28T06:55:48+00:00

15. Pronin, S. V.; Shenvi, R. A. Synthesis of a Potent Antimalarial Amphilectene. J. Am. Chem. Soc. 2012, 134, 19604-19606.

14. Synthesis of Highly Strained Terpenes by Nonstop Tail-to-Head Polycyclization2024-06-28T06:56:20+00:00

14. Pronin, S. V.; Shenvi, R. A. Synthesis of Highly Strained Terpenes by Nonstop Tail-to-Head Polycyclization. Nature Chem. 2012, 4, 915-920.

13. A Stereoselective Hydroamination Transform to Access Polysubstituted Indolizidines2024-06-28T06:56:59+00:00

13. Pronin, S. V.; Tabor, M. G.; Jansen, D. J.; Shenvi, R. A. A Stereoselective Hydroamination Transform to Access Polysubstituted Indolizidines. J. Am. Chem. Soc. 2012, 134, 2012-2015.

  • In top ten most accessed articles of J. Am. Chem. Soc. for January 2012.
  • Highlighted in Nature Chemistry, May 2012.
​12. Scalable Synthesis of Cortistatin A and Related Structures2024-06-28T06:58:28+00:00

​12. Shi, J.; Manolikakes; G. Yeh, C.-H.; Guerrero, C. A.; Shenvi, R. A.; Shigehisa, Hiroki; Baran, P. S. Scalable Synthesis of Cortistatin A and Related StructuresJ. Am. Chem. Soc. 2011, 133, 8014-8027.

​11. Synthetic Access to Bent Polycycles by Cation-Pi Cyclizatio2024-06-28T06:58:43+00:00

​11. Shenvi, R. A.; Corey, E. J. Synthetic Access to Bent Polycycles by Cation-Pi CyclizationOrg. Lett. 2010, 12, 3548-3551.​

10. A Short and Efficient Synthesis of (–)-7-Methylomuralide, a Potent Proteasome Inhibitor2024-06-28T06:58:59+00:00

10. Shenvi, R. A.; Corey, E. J. A Short and Efficient Synthesis of (–)-7-Methylomuralide, a Potent Proteasome Inhibitor. J. Am. Chem. Soc., 2009, 131, 5746-5747.

​9. Stereodivergent Synthesis of 17-α and 17-β-Aryl Steroids: Application and Biological Evaluation of D-Ring Cortistatin Analogue2024-06-28T06:59:18+00:00

​9. Shi, J.; Shigehisa, H.; Guerrero, C. A.; Shenvi, R. A.; Li, R. A.; Baran, P. S. Stereodivergent Synthesis of 17-α and 17-β-Aryl Steroids: Application and Biological Evaluation of D-Ring Cortistatin AnaloguesAngew. Chem. Int. Ed. 2009, 48, 4328-4331.

8. Chemoselectivity: The Mother of Invention in Total Synthesis2024-06-28T06:59:34+00:00

​8. Shenvi, R. A.; O’Malley, D. P.; Baran, P. S. Chemoselectivity: The Mother of Invention in Total Synthesis. Acc. Chem. Res. 2009, 42, 530-541.

​7. Pure and Applied Science in the Chemical Syntheses of Marine Alkaloids Chartelline C and Cortistatin2024-06-28T06:59:57+00:00

​7. Shenvi, R. A. (2008). Pure and Applied Science in the Chemical Syntheses of Marine Alkaloids Chartelline C and Cortistatin A. Ph.D. Thesis, The Scripps Research Institute, 2008.

6. Synthesis of (+)-Cortistatin2024-06-28T07:00:15+00:00

​6. Shenvi, R. A.; Guerrero, C. A.; Shi, J.; Li, C.-C.; Baran, P. S. Synthesis of (+)-Cortistatin A. J. Am. Chem. Soc. 2008, 130, 7241-7243.

​5. Total Synthesis of (±)-Chartelline2024-06-28T07:00:33+00:00

​5. Baran, P. S.; Shenvi, R. A. Total Synthesis of (±)-Chartelline C. J. Am. Chem. Soc. 2006, 128, 14028-14029.

​4. One-Step Synthesis of 4,5-Disubstituted Pyrimidines Using Commercially Available and Inexpensive Reagents2024-06-28T07:00:56+00:00

​4. Baran, P. S.; Shenvi, R. A.; Nguyen, S. A. One-Step Synthesis of 4,5-Disubstituted Pyrimidines Using Commercially Available and Inexpensive ReagentsHeterocycles. 2006, 70, 581-586.

​3. A Remarkable Ring Contraction En Route to the Chartelline Alkaloids2024-06-28T07:01:17+00:00

​3. Baran, P. S.; Shenvi, R. A., Mitsos, C. A. A Remarkable Ring Contraction En Route to the Chartelline Alkaloids. Angew. Chem. Int. Ed. 2005, 44, 3714-3717.

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